JORDI TAMARIT SUMALLA

JORDI TAMARIT SUMALLA

Agregat

Researcher ID: C-6316-2008
Àrea de coneixement : Bioquímica i Biologia Molecular

Grup de Recerca: Estrès cel·lular i supervivència en models eucariotes

Informació de contacteMIMO
Ciències Mèdiques Bàsiques
Departament de Ciències Mèdiques Bàsiques, IRBLleida, Universitat de Lleida, Edifici Biomedicina 1, Av. Rovira Roure 80
973702475
jordi.tamarit(a)cmb.udl.cat

Publicacions en revistes

Alsina D; Purroy R; Ros J; Tamarit J. Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon?. En Pharmaceuticals. 2018 . Repositori Institucional
Alsina D, Ros J, Tamarit J. Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxin-deficient yeast. En Redox Biology. Volum 14. 2018 . Repositori Institucional
Purroy R; Britti E; Delaspre F; Tamarit J; Ros J. Mitochondrial pore opening and loss of Ca2+ exchanger NCLX levels occur after frataxin depletion. En Biochimica et Biophysica Acta-Molecular Basis of Disease. Volum 1864. Número 2. 2018 . https://doi.org/10.1016/j.bbadis.2017.12.005
Britti E, Delaspre F, Feldman A, Osborne M, Greif H, Tamarit J, Ros J. Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment. En Journal Of Cellular And Molecular Medicine. 2017 . Repositori Institucional
Tamarit J; Obis E; Ros J. Oxidative stress and altered lipid metabolism in Friedreich ataxia. En Free Radical Biology and Medicine. Volum 100. 2016
Obis È, Irazusta V, Sanchís D, Ros J, Tamarit J. Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism. En Free Radical Biology and Medicine. Volum 73. 2014 . Repositori Institucional
Mincheva-Tasheva S, Obis E, Tamarit J, Ros J. Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-x(L) protein. En Human Molecular Genetics. Volum 23. Número 7. 2014 . Repositori Institucional
Cabiscol E, Tamarit J, Ros J. Protein carbonylation: proteomics, specificity and relevance to aging. En Mass Spectrometry Reviews. Volum 33. Número 1. 2014 . Repositori Institucional
Moreno-Cermeño A, Alsina D, Cabiscol E, Tamarit J, Ros J. Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1. En Biochimica et Biophysica Acta-Molecular Cell Research. Volum 1833. Número 12. 2013 . Repositori Institucional
Rodriguez-Colman MJ; Sorolla MA; Vall-llaura N; Tamarit J; Ros J; Cabiscol E. The FOX transcription factor Hcm1 regulates oxidative metabolism in response to early nutrient limitation in yeast. Role of Snf1 and Tor1/Sch9 kinases. En Biochimica et Biophysica Acta-Molecular Basis of Disease. Volum 1833. Número 8. 2013 . Repositori Institucional
Tamarit J, de Hoogh A, Obis E, Alsina D, Cabiscol E, Ros J. Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides. En Journal Of Proteomics. Volum 75. Número 12. 2012 . Repositori Institucional
Sorolla MA, Rodríguez-Colman MJ, Vall-llaura N, Tamarit J, Ros J, Cabiscol E. Protein oxidation in Huntington disease. En Biofactors. Volum 38. Número 3. 2012 . Repositori Institucional
Sorolla MA, Nierga C, Rodríguez-Colman MJ, Reverter-Branchat G, Arenas A, Tamarit J, Ros J, Cabiscol E. Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation. En Archives of Biochemistry and Biophysics. Volum 510. Número 1. 2011 . Repositori Institucional
Moreno-Cermeno A, Obis E, Belli G, Cabiscol E, Ros J, Tamarit J. Frataxin depletion in yeast triggers upregulation of iron transport systems before affecting iron-sulfur enzymes activities. En Journal of Biological Chemistry. Volum 285. Número 53. 2010 . Repositori Institucional
Rodriguez-Colman MJ, Reverter-Branchat G, Sorolla MA, Tamarit J, Ros J, Cabiscol E. The Forkhead Transcription Factor Hcm1 Promotes Mitochondrial Biogenesis and Stress Resistance in Yeast. En Journal of Biological Chemistry. Volum 285. Número 47. 2010 . Repositori Institucional
Sorolla MA, Rodríguez-Colman MJ, Tamarit J, Ortega Z, Lucas JJ, Ferrer I, Ros J, Cabiscol E. Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism. En Free Radical Biology and Medicine. Volum 49. Número 4. 2010 . Repositori Institucional
Irazusta V, Obis E, Moreno-Cermeno A, Cabiscol E, Ros J, Tamarit J. Yeast frataxin mutants display decreased superoxide dismutase activities crucial to promote protein oxidative damage. En Free Radical Biology and Medicine. Volum 48. Número 3. 2010 . Repositori Institucional
Irazusta V.; Moreno Cermeño A.; Cabiscol E.; Tamarit J.; Ros J. Proteomic strategies for the analysis of carbonyl groups on proteins. En Current Protein & Peptide Science. Volum 11. Número 8. 2010
Irazusta V, Moreno-cermeño A, Cabiscol E, Ros J, Tamarit J. Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins. En Free Radical Biology and Medicine. Volum 44. Número 9. 2008 . Repositori Institucional
Sorolla MA, Reverter-Branchat G, Tamarit J, Ferrer I, Ros J, Cabiscol E. Proteomic and oxidative stress analysis in human brain samples of Huntington disease. En Free Radical Biology and Medicine. Volum 45. Número 5. 2008 . Repositori Institucional
Verónica Irazusta, Armando Moreno-Cermeño, Joaquim Ros, Jordi Tamarit. Estratégias proteómicas para el análisis de grupos carbonilo como marcadores de daño oxidativo en proteínas. En Proteomica. Volum 2. 2008
Reverter-Branchat G, Cabiscol E, Tamarit J, Sorolla MA, de la Torre MA, Ros J. Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1. En Microbiology-Sgm. Volum 153. Número 18. 2007 . Repositori Institucional
Irazusta V, Cabiscol E, Reverter-Branchat G, Ros J, Tamarit J. Manganese is the link between frataxin and iron-sulfur deficiency in the yeast model of Friedreich ataxia. En Journal of Biological Chemistry. Volum 281. Número 18. 2006 . Repositori Institucional
Tamarit J, Irazusta V, Moreno-Cermeno A, Ros J. Colorimetric assay for the quantitation of iron in yeast. En Analytical Biochemistry. Volum 351. Número 1. 2006 . Repositori Institucional
Herrero E, Ros J, Tamarit J, Belli G. Glutaredoxins in fungi. En Photosynthesis Research. Volum 89. Número 2-3. 2006 . Repositori Institucional
Garcera A, Barreto L, Piedrafita L, Tamarit J, Herrero E. Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases. En Biochemical Journal. Volum 398. Número 2. 2006 . Repositori Institucional
Reverter-Blanchat G, Cabiscol E, Tamarit J, Ros J. Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae. Common targets and prevention by calorie restriction. En Journal of Biological Chemistry. Volum 279. Número 30. 2004 . Repositori Institucional
Echave P, Tamarit J, Cabiscol E, Ros J. Novel antioxidant role of alcohol dehydrogenase E from Escherichia coli. En Journal of Biological Chemistry. Volum 278. 2003 . Repositori Institucional
Tamarit J, Bellí G, Cabiscol E, Herrero E, Ros J. Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin. En Journal of Biological Chemistry. Volum 278. 2003 . Repositori Institucional
Cabiscol E, Bellí G, Tamarit J, Echave P, Herrero E, Ros J. Mitochondrial Hsp60, resistance to oxidative stress and the labile iron pool are closely connected in Saccharomyces cerevisiae. En Journal of Biological Chemistry. Volum 277. 2002 . Repositori Institucional
Echave P, Esparza-Ceron MA, Cabiscol E, Tamarit J, Ros J, Membrillo-Hernandez J, Lin ECC. DnaK dependence of mutant ethanol oxidoreductases evolved for aerobic function and protective role of the chaperone against protein oxidative damage in Escherichia coli. En Proceedings of the National Academy of Sciences of the United States of America. Volum 99. 2002 . Repositori Institucional
Bellí G, Polaina J, Tamarit J, De La Torre MA, Rodriguez-Manzaneque MT, Ros J, Herrero E. Structure-function analysis of yeast Grx5 monothiol glutaredoxin defines essential amino-acids for the function of the protein. En Journal of Biological Chemistry. Volum 277. 2002
Rodríguez-Manzaneque MT, Tamarit J, Bellí G, Ros J, Herrero E. Grx5 is a mitochondrial glutaredoxin required for the maturation of iron/sulfur enzymes. En Molecular Biology of the Cell. Volum 13. 2002 . Repositori Institucional
Membrillo-Hernández J, Echave P, Cabiscol E, Tamarit J, Ros J, Lin ECC. Evolution of the AdhE gene product of E. coli from a functional reductase to a dehydrogenase. En Journal of Biological Chemistry. Volum 275. 2000 . Repositori Institucional
Cabiscol E, Tamarit J, Ros J. Oxidative stress in Bacteria and protein damage by reactive oxygen species. En International Microbiology. Volum 3. 2000 . Repositori Institucional
Tamarit J, Gerez C, Mulliez E, Meier C, Trautwein A, Fontecave M. The activating component of the anaerobic ribonucleotide reductase from Escherichia coli: an iron-sulfur center with only three cysteines. En Journal of Biological Chemistry. Volum 275. 2000 . Repositori Institucional
Tamarit J, Mulliez E, Meier C, Trautwein A, Fontecave M. The anaerobic ribonucleotide reductase from Escherichia coli: The small protein is an activating enzyme containing a[4Fe4S]2+center. En Journal of Biological Chemistry. Volum 274. 1999 . Repositori Institucional
Lu Z, Cabiscol E, Obradors N, Tamarit J, Ros J, Aguilar J, Lin ECC. Evolution of an E. Coli protein with increased resistance to oxidative stress. En Journal of Biological Chemistry. Volum 273. Número 14. 1998 . Repositori Institucional
Tamarit J, Cabiscol E, Ros J. Identification of the major oxidatively damaged proteins in E. Coli cells exposed to exidative stress. En Journal of Biological Chemistry. Volum 273. Número 5. 1998 . Repositori Institucional
Tamarit J, Cabiscol E, Aguilar J, Ros J. Differential innactivation of alcohol dehydrogenase isoenzymes in zymomonas mobilis by oxigen. En Journal of Bacteriology. Volum 179. 1997 . Repositori Institucional
Elena Britti; Fabien Delaspre; Jordi Tamarit; Joaquim Ros. Mitochondrial calcium signaling and neurodegenerative diseases. En Neuronal signaling. Volum 2. Número 4. 2018 . Repositori Institucional
Elena Britti; Fabien Delaspre; Jordi Tamarit; Joaquim Ros. Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis. En Neurochemical Research. 2020 . https://doi.org/10.1007/s11064-020-03020-3
Rosa Purroy; Marta Medina-Carbonero; Joaquim Ros; Jordi Tamarit. Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase. En Redox Biology. 2020 . https://doi.org/10.1016/j.redox.2020.101520

Formació acadèmica

Llicenciat en Biologia . Universitat de Barcelona . 07/1993 . (Diplomatura / Llicenciatura / Grau)
Doctor en Biologia . Universitat de Lleida . 07/1997 . (Doctorat )

Textos del currículum

Trajectòria.

Jordi Tamarit earned a Bachelor in Biology from the Universitat de Barcelona in 1993. In January 1994 he was awarded a FPU predoctoral fellowship to carry out the doctoral thesis at the Department of Basic Medical Sciences from the Universitat de Lleida. His thesis was directed by Joaquim Ros and it was focused on the effects of oxidative stress on proteins.

After obtaining a PhD in the summer of 1997, he joined the Atomic Energy Commission in Grenoble, France, to work in the laboratory led by Professor Marc Fontecave (Chimie et Biochimie des Centers Redox Biologiques). During this postdoctoral phase he focused on the characterization of the iron-sulfur cluster from Ribonucleotide Reductase class III. In February 2000 he joined again Universitat de Lleida thanks to the RED program (reincorporation of doctors) promoted by Generalitat de Catalunya. In the following years, his work consisted in the characterization of Grx5 from Saccharomyces cerevisiae, a protein involved in the biosynthesis of iron-sulfur clusters.

In 2003, he was awarded a Ramon y Cajal fellowship and his research focused on the study of the effects of oxidative stress generated by the accumulation of iron in cells. The accumulation of iron is associated with several pathologies, such as some hereditary ataxias, hemochromatosis or aceruloplasminemia. Since 2007 he is assistant professor (professor agregat) of biochemistry at Universitat de Lleida and researcher at IRBLleida. His recent reasearch is mostly focused on Friedreich ataxia, a rare disease caused by deficiency in the mitochondrial protein frataxin. This protein is involved in cellular iron homeostasis and oxidative stress protection.
Docència Impartida.

Grau en Ciències Biomèdiques

- Proteòmica i Enginyeria de Proteïnes

- Estrès en sistemes biològics, envelliment i patologia vascular

Grau en Biotecnologia

- Proteòmica i Enginyeria de Proteïnes

Màster en investigació Biomèdica

- Mètodes en Biologia de Sistemes

- Estrès Oxidatiu i Antioxidants