FABIEN DELASPRE

FABIEN DELASPRE

Investigador Postdoctoral

Scopus Author ID: 22950014100
Researcher ID: M-3654-2015
Àrea de coneixement : Bioquímica i Biologia Molecular

Grup de Recerca: Estrès cel·lular i supervivència en models eucariotes

Informació de contacte
Ciències Mèdiques Bàsiques
Biochemistry of Oxidative Stress Group Universitat de Lleida / IRBLleida Biomedicina 1 - b4.13 Av Rovira Roure, 80
0034973702490
fabien.delaspre(a)udl.cat

Activitats anteriors

Post-Doctoral Fellow. Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, US. 30/06/2011 - 30/06/2015
PhD candidate. Institut Hospital del Mar d'Investigacions Mèdiques PRBB Barcelona, Spain. 21/03/2006 - 31/12/2010
Research Assistant. LIPM Toulouse. 30/11/2005 - 01/03/2006
BIOQUÍMICA I METABOLISME - Doble titulació: Grau en Nutrició Humana i Dietètica i Grau en Fisioteràp. Universitat de Lleida - Campus Igualada. 01/02/2017

Publicacions en revistes

Purroy R; Britti E; Delaspre F; Tamarit J; Ros J. (2018). Mitochondrial pore opening and loss of Ca2+ exchanger NCLX levels occur after frataxin depletion. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(2), pp. 618 - 631 . https://doi.org/10.1016/j.bbadis.2017.12.005 . ISSN: 0925-4439
Elena Britti; Fabien Delaspre; Jordi Tamarit; Joaquim Ros. (2018). Mitochondrial calcium signaling and neurodegenerative diseases. Neuronal signaling, 2(4), p. NS20180061 . Repositori Institucional . ISSN: 2059-6553
Britti E, Delaspre F, Feldman A, Osborne M, Greif H, Tamarit J, Ros J. (2017). Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment. Journal Of Cellular And Molecular Medicine . Repositori Institucional . ISSN: 1582-4934
Antonella Mangraviti; Tula Raghavan; Francesco Volpin; Nicolas Skuli; David Gullotti; Jinyuan Zhou; Laura Asnaghi; Eric Sankey; Ann Liu; Yuan Wang; Dong-Hoon Lee; Noah Gorelick; Riccardo Serra; Michael Peters; Destiny Schriefer; Fabien Delaspre; Fausto J. Rodriguez; Charles G. Eberhart; Henry Brem; Alessandro Olivi; Betty Tyler (2017). HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy. Scientific Reports, 7(14978) . Repositori Institucional . ISSN: 2045-2322
Wei Huang; Rebecca L. Beer; Fabien Delaspre; Guangliang Wang; Hannah E. Edelman; Hyewon Park; Mizuki Azuma; Michael J. Parsons (2016). Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation. Developmental Biology, 418(1), pp. 28 - 39 . https://doi.org/10.1016/j.ydbio.2016.08.019 . ISSN: 0012-1606
Guangliang Wang, Surendra K. Rajpurohit, Fabien Delaspre, Steven L. Walker, David T. White, Alexis Ceasrine, Rejji Kuruvilla, Ruo-jing Li, Joong S. Shim, Jun O. Liu, Michael J. Parsons, Jeff S. Mumm (2015). First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. Elife, 4, p. e08261 . Repositori Institucional . ISSN: 2050-084X
Fabien Delaspre, Rebecca L. Beer, Meritxell Rovira, Wei Huang, Guangliang Wang, Stephen Gee, Maria del Carmen Vitery, Sarah J. Wheelan, and Michael J. Parsons (2015). Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration. Diabetes, 64(10), pp. 3499 - 3509 . https://doi.org/10.2337/db15-0153 . ISSN: 0012-1797
Wei Huang, Guangliang Wang, Fabien Delaspre, Vitery MdC, Rebecca Beer, Michael J. Parsons (2014). Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Developmental Biology . https://doi.org/10.1016/j.ydbio.2014.07.021 . ISSN: 0012-1606
Fabien Delaspre, Mohammad Massumi, Marta Salido, Bernat Soria, Philippe Ravassard, Pierre Savatier, Anouchka Skoudy (2013). Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors. Plos One, 8(1), p. e54243 . Repositori Institucional . ISSN: 1932-6203
Britti, E.; Delaspre, F.; Tamarit, J.; Ros, J. (2020). Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis. Neurochemical Research . https://doi.org/10.1007/s11064-020-03020-3 . ISSN: 0364-3190
Medina Carbonero, M.; Sanz Alcázar, A.; Britti, E.; Delaspre, F.; Cabiscol, E.; Ros, J.; Tamarit, J. (2022). Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations. Cell Mol Life Sci, 79 . Repositori Institucional
Britti, E.; Delaspre, F.; Sanz-Alcázar, A.; Medina-Carbonero, M.; Llovera, M.; Purroy, R.; Mincheva-Tasheva, S.; Tamarit, J.; Ros, J. (2021). Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia. Biochemical Journal, 478(1), pp. 1 - 20 . Repositori Institucional . ISSN: 0264-6021
Tamarit, J.; Britti, E.; Delaspre, F.; Medina Carbonero, M.; Sanz Alcázar, A.; Cabiscol, E.; Ros, J. (2021). Mitochondrial iron and calcium homeostasis in Friedreich ataxia. IUBMB Life, 73(3), pp. 543 - 553 . https://doi.org/10.1002/iub.2457 . ISSN: 1521-6543
Rodríguez-Pascau L; Britti E; Calap-Quintana P; Dong YN; Vergara C; Delaspre F; Medina-Carbonero M; Tamarit J; Pallardó FV; Gonzalez-Cabo P; Ros J; Lynch DR; Martinell M; Pizcueta P (2020). PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia. Neurobiology of Disease, 148, pp. 105162 - 105162 . Repositori Institucional . ISSN: 0969-9961